General Information

  • ID:  hor000843
  • Uniprot ID:  E9H4H6
  • Protein name:  Ecdysis-triggering hormone 2
  • Gene name:  ETH
  • Organism:  Daphnia pulex (Water flea)
  • Family:  NA
  • Source:  Animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Daphnia (genus), Daphniidae (family), Anomopoda (infraorder), Cladocera (suborder), Diplostraca (order), Phyllopoda (subclass), Branchiopoda (class), Crustacea (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  NA
  • GO CC:  NA

Sequence Information

  • Sequence:  GEGIIAEYMNSESFPHEGSLSNFFLKASKAVPRL
  • Length:  34(48-81)
  • Propeptide:  MYRELIMIKGLFLTWLLLASALSDPSPEPFNPNYNRFRQKIPRIGRRGEGIIAEYMNSESFPHEGSLSNFFLKASKAVPRLGRRKDISTESGRAAMVGEEPFGRISNEIPIMNQKQDLWPNMNINELTGALNKELNYPGPRIPKDLQDNYIQDLIHSWINQYENLNEN
  • Signal peptide:  MYRELIMIKGLFLTWLLLASA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  NA
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:   NA
  • IC50:  NA
  • EC50:  NA
  • ED50:  NA
  • Kd:  NA
  • Half life:  NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-E9H4H6-F1(AlphaFold_DB_ID)
  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
  •    hor000843_AF2.pdbhor000843_ESM.pdb

Physical Information

Mass: 431598 Formula: C168H257N43O51S
Absent amino acids: CDQTW Common amino acids: S
pI: 5.64 Basic residues: 4
Polar residues: 11 Hydrophobic residues: 12
Hydrophobicity: -17.35 Boman Index: -4016
Half-Life / Aliphatic Index: 30 hour Aliphatic Index: 74.71
Instability Index: 3117.35 Extinction Coefficient cystines: 1490
Absorbance 280nm: 45.15

Literature

  • PubMed ID:  21830762
  • Title:  Genomics, Transcriptomics, and Peptidomics of Daphnia Pulex Neuropeptides and Protein Hormones